![]() Fauci, M.D., director of NIH’s National Institute of Allergy and Infectious Diseases (NIAID). “These findings suggest that this experimental gene therapy could serve as a potential treatment option for infants and older children with ADA-SCID,” said Anthony S. Prior gene therapy trials for ADA-SCID used a gamma retrovirus to transfer the gene into the stem cells, resulting in leukemia in some patients. ![]() The virus, or vector, is different from the one researchers used in past gene therapy clinical trials for ADA-SCID. The absence of this enzyme leads to an accumulation of toxic metabolic by-products within lymphocytes that cause infection-fighting cells to die.įor these most recent clinical trials, researchers used a modified lentivirus to deliver a corrected copy of the ADA gene into the patients’ stem cells. The research study took place in both the United States and the United Kingdom.Ĭhildren with ADA-SCID lack an important enzyme called adenosine deaminase (ADA), essential for the metabolic function of a variety of cells, especially T cells. ![]() The researchers, funded in part by the National Institutes of Health, found that 48 out of 50 infants and children with ADA-SCID treated with gene therapy experienced a restored immune system within a period of two to three years and did not require additional treatments. ![]() Research findings recently published in the New England Journal of Medicine provide hope that gene therapy may one day be an accepted treatment for ADA-SCID instead of an experimental one.īabies born with severe combined immunodeficiency, or SCID, have no immune system and die from infection within the first year or two of life unless they undergo treatment to restore their immune system. ![]()
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![]() ![]() Imagine going to the grocery store just once because your grocery shopping list is that comprehensive! It’s the best way to ensure you don’t forget any side dishes or overlook important details. With everything from a Thanksgiving guest list to recipe cards and even Thanksgiving shopping list, this planner is designed to give busy moms a break. This is where the free Thanksgiving planner printables come to the rescue! This time of year can be a whirlwind, but a Thanksgiving dinner checklist can be a huge help. ![]() Or maybe it was your first year hosting and you felt overwhelmed by the sheer volume of things to get done. Last year, did you find yourself running back to the grocery store multiple times? Organizing such a big event like Thanksgiving dinner requires more than just a good memory. 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You can quickly segment your huge music collection into “Chillout”, “Opening DJ Set”, “Mid-Set”, “Bangers” and other playlists based on the energy level of each track.įlow ranks every track on a scale of 1 to 10 to show you how energetic the track will sound in the club. Create great playlists & play them well.įlow helps you create playlists for different vibes and moods. See what Pioneer, Traktor and Numark controllers you can use with Flow. Our #1 goal is to help you sound perfect in the DJ booth. Our software will analyze your music collection and find the most accurate Mixed In Key result for every track. Finish the foundation of your track, and export it to your. ![]() remix of it, using Odesi’s chords, melody and bassline tools. Detect the Key and Scale of any audio file and write a new. Use the best Harmonic Mixing technology.įlow was launched by the award-winning team that created Mixed In Key. Write chord progressions that add mood to your music. 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Flow analyzes your music, and splits every track into 8 perfect loops. ![]() ![]() ![]() Sitting in a noisy restaurant for an hour or two, or a motorcycle whizzing past you is not going to really cause any harm to your hearing – otherwise, restaurants would be out of business. While this was solely about toxicology, the basic principle translates to our example here the decibel level (depending) is not always the issue but the time spent exposed to it is. In the words of Swiss physician, Paracelsus: “the dosage makes the poison”. Two of the most important aspects to remember when it comes to this potentially dangerous dB level, include the amount of time spent in these environments, distance, and natural noise suppression. ![]() Before you rush off to grab your nearest pair of noise-canceling headphones, there are some other factors to consider as to why this isn’t an inherently bad thing. Examples include heavy traffic, a motorcycle, and even a noisy restaurant. There are a number of everyday sounds that meet, or edge over, the 85dB level which can impact your hearing. Still, it’s important to understand that there are a wide variety of factors that you should consider as well. ![]() You needn’t worry too much – examples of 120dB sound include live indoor music concerts and jet engines. Also, if these hair cells are sufficiently damaged, they can die, which would lead to permanent hearing loss. Unfortunately, hair cells cannot regenerate, regrow, or heal, and so if they are damaged, they can never return to full function, diminishing your hearing ability. These hairs in your cochlea react to the vibrations from incoming sound waves, and are responsible for sending electrical signals to your brain to process the sound. Sounds at these intense levels can also damage the tiny hairs, stereocilia, in your ears. This won’t be immediate, but you will not need to be exposed to these sounds for very long periods for the effects to take hold.Īs this isn’t an exact science, there is no determining how long you can be bombarded with sound at 85dB or higher, so it’s considered best practice to remove yourself as quickly as possible from the noisy area, or put on safety equipment as quickly as possible.įurthermore, any sound at 120dB will have an immediate impact on your hearing, and in some cases, can be severe enough to rupture your eardrum as soon as it hits your ears. ![]() Sounds at, or above, this level can have lasting, permanent effects on your hearing, and will most likely lead to a reduction in your hearing ability. Theoretically speaking, any noise level that is above 85dB is considered harmful to one’s hearing. There are a number of influencing factors that we need to factor in, such as how long we are exposed to the noise, whether we are using safety equipment and the fact that everyone’s hearing, and sensitivity to sounds, is unique. We hear so many sounds on a daily basis, and all at various volume levels, so it’s only natural to wonder at what point we may be damaging our hearing.Īs with a number of other “harmful” things, it’s not as clear-cut as we would like it to be. At one point or another, you might have wondered “what decibel level is harmful to my ears”. ![]() ![]() If you have installed any expansion packs, check the requirements for them in Origin as they need some extra computing power. If you’re having trouble installing or launching your game, the first thing to check is that your system meets the minimum requirements for The Sims 3. Once it’s finished installing, open the game and you’re all set to start a new household in your new world. The Sims 3 launcher will start up and install your world. ![]() When you click on a World in your Purchase History to download it, you may get a pop-up message asking permission to open a URL: You can also find any worlds you bought previously from on that same page. If it doesn’t start automatically, you can download your World from your Purchase History page on. Once you’ve done that, The Sims 3 launcher will start up and install your world. If you buy a World, or World Bundle, through Origin, we email you a code to redeem on : Some Worlds are available to buy through Origin, on their own or as part of a bundle – others (including the free World, Riverview) are only available on. You should always launch The Sims 3 using the disc for the most recent game expansion or stuff pack you have installed, and you will need to use your disc every time you play. When you’re done, use the super-patcher to update your game to the latest version (Version number 1.67.62). The Sims 3: Katy Perry's Sweet Treats Stuff.If you’re installing from disc, we recommend installing expansions and stuff packs in the order they were released. Only the items marked active will show in game. Origin also keeps your game updated for you.ĭon’t forget to activate the expansions you want to see in the game once they are installed. You do not need to install your expansions and Stuff Packs in any special order if you are installing them through Origin. ![]() If installation doesn’t start right away, double-click on the drive to kick it off. Put your game disc into your drive, and follow the instructions on-screen. If the game installation doesn’t start automatically, double-click on your DVD drive in My Computer to start the installer. Put your game disc into your DVD drive and follow the instructions on-screen. Make sure you have it ready before you start the installation. When you’re installing from game discs, you need to type in your game code to install your game. If you're playing on disc (not through Origin) your game won't update past version 1.67. If you want the latest version of The Sims 3, download and install Origin, and it will update your game for you. If you’re playing on PC, use The Sims 3 expansion and Stuff pack manager to choose which expansions and Stuff packs you play with. If you need to reinstall something, or something you’ve bought does not download automatically, find it in the Origin client and click Download. If you’re having technical trouble and want to reinstall your game, make sure you back up your saves first!Īlways install The Sims 3 base game before installing any expansions, stuff packs, worlds or store content.Īnything you buy through Origin is added to your download queue.
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Here's a quick rundown of what Scyther is capable of: I also plan on making a Journal entry explaining how a lot of the new stuff works too, in the context of MUGEN coding, so look forward to that too! def file (where the coding is, of course), to help explain the purpose of all of the new coding. My hope is to help inspire others into pushing their vore creations ever further and beyond, so in addition to shoving as many ideas as I could in here, I also included all of the spritework/sfx that were used for this edit, and I also left TONS of notes within Scyther's. I spent a lot of time screwing around with MUGEN coding so as to come up with as many new innovations as I could. Unlike Scizor, though, this Scyther submission actually has a lot of features that are new (or at the least, not fully explored) in the MUGEN vore scene. And with a subject so similar to my previous submission, no less! ![]() (Unlike my previous submissions, I can't seem to locate a download link for the original version of this Scyther. IMPORTANT: This character was designed for MUGEN 1.0! If you use him in 1.1, his vore moves may not function properly in team battles! (Though he should be fine in single battles regardless.) ![]() ![]() Purpose: Ensure the design template lines up with your meant usage.Printable design templates cover many applications, from invites to business cards, calendars to leaflets, making jobs more available and effective. They offer a structure for people or companies to construct, guaranteeing consistency, professionalism, and imagination. Printable design templates are pre-designed designs or formats that can be printed straight or personalized to fit particular requirements. 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![]() Shaders designed for in-game photography.įun and abstract effects like Swirl, Wave, Slit Scan, etc. Shaders ported from RetroArch to ReShade, home of many CRT shaders.Ĭontains alternative implementation of Ambient Occlusion and Tonemapping. Home of some utility shaders such as Fog Removal. Home of a few "enhanced" versions of known shaders. Home of many advanced color grading shaders + many photoshop-like ones. Really neat lesser known shader repository. Home of a few bloom shaders like NeoBloom, MagicHDR and other utility shaders like AspectRatioSuite, ArtisticVignette, FlexibleCA, MinimalColorGrading and NormalMap. ![]() Home of Eye Adaptation and UI Detect shaders. Home of the Comic, ColorIsolation, AspectRatioComposition, HotsamplingHelper and other shaders. Home of Perfect Perspective (fov correction/distortion), Chromakey, Filmic Anamorphic Sharpen, Reflection (matcap), VR and other filmic shaders like Prism and Letterbox. Home of SuperDepth3D (adds 3D support on almost any game) Home of Smart Sharp, Temporal AA, NFAA, BloomingHDR and others. Various anti-aliasing shaders and more (used to be part of Depth3D). Home of Cinematic DOF and other utility shaders. All these shaders have been worked from the ground up and provide staggering performance and visuals in comparison to their qUINT counterparts. ![]() Hosts effects such as Launchpad, MXAO, Sharpen, and SMAA. Marty McFly's new repository to be replacing qUINT soon. ![]() Home of MXAO (ambient occlusion), Lightroom, Advanced DOF, DELCS (sharpening), Bloom and other utility shaders. Home of many useful effects like SMAA, FXAA, LumaSharpen and CAS, as well as many ports of effects from the SweetFX injector. The original shader suite that ReShade was created to support. Required for most shaders, should be installed automatically by the setup tool. Although reshade-shaders is the official shader repository, shaders can be downloaded from anywhere. ![]() |
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